Welcome to the Huang lab!

We are a new research group interested in understanding molecular mechanisms of protein complexes, in particular large protein assemblies, through studying their structures, dynamics and functions. We use advanced Nuclear Magnetic Resonance (NMR) techniques in combination with other structural biology tools, such as cryo-Electron Microscopy and Mass Spectrometry, as well as other biophysical and biochemical techniques to determine the 3D structures of the proteins, study protein-protein interactions, characterize their functional dynamics, and provide information and strategies to design therapeutics for intervening their functions.

If you are passionate about learning how proteins work and studying their structures, dynamics and functions, join us! We are recruiting lab members of all levels, see here.

LAB NEWS

Dr. Huang gave a talk in ICMRBS-ECR conference series!

Dr. Rui Huang presented the study on p97-p47 interaction in the ICMRBS-ECR conference series. Video link will be posted soon!
— Feb 2021

Study featured in CEPS research news!

Dr. Rui Huang and collaborators’ study on the cooperativity of a p97 mutant was featured in University of Guelph College of Engineering and Physical Sciences (CEPS) research news! Check it out here.
— Feb 2021

Dr. Huang’s study on p97-p47 interaction came out on PNAS!

Dr. Rui Huang and collaborators’ study on the interaction between an AAA ATPase p97 and its adaptor p47 was published on PNAS! Check it out here.
— Oct 2020

Dr. Huang’s study on the synergy between cryo-EM and NMR on p97 was published on Angew Chem Int Ed Engl!

A study conducted by Dr. Rui Huang and collaborators investigating the cooperativity of a p97 mutant demonstrated the synergy between cryo-EM and NMR in understanding structure and function of large protein complexes. This work was published on Angew Chem Int Ed Engl. Check it out here.
— August 2020

Nicole Chen and Aaron Ovadia join the lab!

Warm welcome to our newest members Nicole Chen and Aaron Ovadia!
— June 01, 2020

Rui starts as PI in Guelph Chemistry

Dr. Rui Huang officially started as an assistant professor in the Department of Chemistry in Guelph. Embarking on an exciting new journey!
— June 01, 2020

Rui joins Guelph

Dr. Rui Huang officially joined the Department of Chemistry in Guelph! She will be starting her new position in June 2020.
— August 2019